Amino Acid and Proliferation PET/CT for the Diagnosis of Multiple Myeloma

Multiple myeloma (MM) is a hematologic malignancy characterized by infiltration of monoclonal plasma cells in the bone marrow (BM). The standard examination performed for assessment lesions has progressed from radiographic skeletal survey to more advanced imaging modalities computed tomography (CT), magnetic resonance (MRI), and positron emission tomography/computed (PET/CT). Durie–Salmon PLUS staging system (upgraded system) applies 2-[ 18 F]-fluoro-2-deoxy-glucose ( F-FDG) PET/CT, MRI findings MM, F-FDG PET/CT been incorporated into International Myeloma Working Group (IMWG) guidelines diagnosis MM. However, significant limitations diffuse BM differentiation MM inflammatory or infectious lesions. potential several new PET tracers that exploit underlying disease mechanism evaluated terms improving diagnosis. L-type amino acid transporter 1 (LAT1), membrane protein transports neutral acids, associated with cell proliferation strong ability represent status This review evaluates compares characteristics accuracy non-FDG management patients